Addenbrooke's exam (ACE-R) is most useful in the
assessment of which condition?
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Obsessive
compulsive disorder
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Alcohol misuse
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Dementia
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Schizophrenia
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Depression
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Addenbrooke's cognitive exam (ACE-R)
The Addenbrooke's cognitive exam was developed following the recognition of limitations of the MMSE such as:-
The exam takes about 15 minutes to do and is divided into five domains (as seen in table below)
Interpretation
The Addenbrooke's has been shown to be a valid tool for detecting dementia. Two cut off points are often used depending on the required sensitivity and specificity.
It has also been shown to be useful in differentiating dementia from pseudo dementia and for detecting cognitive impairment in atypical Parkinson syndromes.
H Bak. A cognitive bedside assessment beyond the MMSE: the Addenbrooke's Cognitive Examination. Practical Neurology, 2007, 7: 245-249.
- Lack of sensitivity for frontal-executive dysfunction
- Lack of sensitivity for visuospatial defects
The exam takes about 15 minutes to do and is divided into five domains (as seen in table below)
| Domain | Points |
|---|---|
| Attention and orientation | 18 |
| Memory | 26 |
| Verbal fluency | 14 |
| Language | 26 |
| Visuospatial | 16 |
| Total | 100 |
Interpretation
The Addenbrooke's has been shown to be a valid tool for detecting dementia. Two cut off points are often used depending on the required sensitivity and specificity.
| Cut off | Sensitivity for detecting dementia | Specificity for detecting dementia |
|---|---|---|
| 88 | 94% | 89% |
| 82 | 84% | 100% |
It has also been shown to be useful in differentiating dementia from pseudo dementia and for detecting cognitive impairment in atypical Parkinson syndromes.
H Bak. A cognitive bedside assessment beyond the MMSE: the Addenbrooke's Cognitive Examination. Practical Neurology, 2007, 7: 245-249.
