Argyll Robertson pupils are most closely associated with which of the following conditions?
Argyll Robertson pupil
Argyll Robertson pupils come up in exams due to the association with tertiary syphilis which remains an important differential for many psychiatric conditions such as dementia, psychosis, and mood disorders.
The Argyll Robertson pupil typically reacts poorly to light and normally to near (accommodation and convergence). They are usually small and irregular in shape. They do not generally lead to a reduction in visual acuity.
Dilation of the Argyll Robertson pupil is typically poor with mydriatic agents.
Argyll Robertson pupils are often said to be pathognomic of tertiary syphilis, however they have also been reported in diabetes.
A common way to remember this is that prostitutes (who often catch syphilis) don't come out in the light (no light reflex) but are very accommodating (with their customers).
