Theme: Schizophrenia risk
Select the lifetime risk of schizophrenia posed to the individual in each of the following
| A. | 5% |
| B. | 0.1% |
| C. | 1% |
| D. | 6% |
| E. | 17% |
| F. | 21% |
| G. | 2% |
| H. | 26% |
| I. | 9% |
| J. | 48% |
Select the lifetime risk of schizophrenia posed to the individual in each of the following
| NaN. | A male patient with schizophrenia attends the outpatient clinic accompanied by his brother. His brother says that he has read on the internet that the condition is genetic and wants to know what his own risk is. You clarify that the brother is a full sibling. What is his brother's risk of developing schizophrenia (based on the Gottesman data)? |
The correct answer is: 9% 60% |
| NaN. | A patient with schizophrenia is visited in hospital by his cousin. The cousin sees you on his way out and says that he read a hospital leaflet about schizophrenia that suggested the condition was genetic. You confirm that he is the patient's first cousin. What would you tell him is his risk of schizophrenia considering that his cousin is affected? |
The correct answer is: 2% 56% |
| NaN. | A psychiatrist is asked to see a young boy in the community who is displaying features of conduct disorder. Whilst inquiring about family history, the parents explain that the boy's grandfather was diagnosed with schizophrenia. There is no other history of this in the family. Based solely on his grandfather's diagnosis, what is the boys lifetime risk of schizophrenia? |
The correct answer is: 5% 43% |
Schizophrenia (Gottesman)
The data on the risk posed to relatives of people with schizophrenia comes from the work of Irving I. Gottesman.
The table below shows Gottesman's famous findings, these are the average risks complied from the family and twin studies conducted in European populations between 1920 and 1987.
You need to commit each one to memory.
| Relationship to person with schizophrenia | Risk of developing schizophrenia (lifetime risk) |
|---|---|
| General population | 1% |
| First cousin | 2% |
| Uncle/aunt | 2% |
| Nephew/niece | 4% |
| Grandchildren | 5% |
| Parents | 6% |
| Half sibling | 6% |
| Full Sibling | 9% |
| Children | 13% |
| Fraternal twins | 17% |
| Offspring of duel matings (both parents had schizophrenia) | 46% |
| Identical twins | 48% |
