Mutations with the granulin genes are most associated with which of the following?
Exam Question Oct 2014
Exam Question Oct 2014
Dementia (genetics)
The following genes have been implicated in dementia.
| Form of dementia | Gene(s) associated |
|---|---|
| Alzheimer's | PSEN1 (presenilin-1), PSEN2 (presenilin-2), APP (amyloid precursor protein), ApoE (apolipoprotein E) |
| Frontotemporal dementia | PGRN (progranulin), MAPT (tau) |
| Huntington's disease | IT15 (huntingtin) |
| CADASIL* | Notch3 (notch 3) |
*CADSIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)
