Neurofibrillary tangles
Neurofibrillary tangles are abnormal aggregations of protein found within neurons. Tangles are formed by hyperphosphorylation of the microtubule associated protein known as Tau, which causes it to clump together in an insoluble form.
Tangles are most commonly found in Alzheimer's disease and were in fact first described by Alois Alzheimer.
They are also seen in other conditions including some of the 'tauopathies' which include:-
The main constituent of amyloid plaques is amyloid protein.
Tangles are most commonly found in Alzheimer's disease and were in fact first described by Alois Alzheimer.
They are also seen in other conditions including some of the 'tauopathies' which include:-
- Frontotemporal dementia
- Dementia pugilistica
- Progressive supranuclear palsy,
The main constituent of amyloid plaques is amyloid protein.
