Norepinephrine
Synthesis
Norepinephrine is synthesised from tyrosine by the following steps. Tyrosine is firstly converted to L-DOPA by tyrosine hydroxylase. L-DOPA is then converted to dopamine by DOPA decarboxylase. Dopamine is then converted to norepinephrine by dopamine beta-hydroxylase. Norepinephrine is then converted to epinephrine by phenylethanolamine-N-methyltransferase.
Release
The main site of norepinephrine release is from the locus coeruleus (aka 'the blue spot) which is located in the pons.
Breakdown
It is broken down by both COMT (catechol-O-methyl transferase) and MAO (monoamine oxidase).
Norepinephrine is synthesised from tyrosine by the following steps. Tyrosine is firstly converted to L-DOPA by tyrosine hydroxylase. L-DOPA is then converted to dopamine by DOPA decarboxylase. Dopamine is then converted to norepinephrine by dopamine beta-hydroxylase. Norepinephrine is then converted to epinephrine by phenylethanolamine-N-methyltransferase.
Release
The main site of norepinephrine release is from the locus coeruleus (aka 'the blue spot) which is located in the pons.
Breakdown
It is broken down by both COMT (catechol-O-methyl transferase) and MAO (monoamine oxidase).
