Psychopharmacology 13

Reduced asymmetry of which of the following structures has been associated with schizophrenia?


Schizophrenia (pathology)


Macroscopic pathological features of schizophrenia include:-

  • Ventricular enlargement
  • Reduced brain volume (up to 5%)
  • Reduced left planum temporale gray matter, and reversed planum temporale surface area asymmetry (normally left larger than right in a right handed person)

The most consistent microscopic findings have been a reduction of the size of the dorsolateral prefrontal cortex and the hippocampus.

Advances in Schizophrenia Research 2009, page 115.