Which of the following is true regarding diazepam?
Exam Question Jul 2014
Exam Question Aug 2010
Diazepam is 95% protein bound and highly lipid soluble meaning that it readily crosses the blood brain barrier. The absorption rate is slowed by the presence of food. It has a long half life of 20-100 hours.
It is 95% protein bound57%It does not cross the blood brain barrier13%It has a half life of 5-10 hours6%Bioavailability is equal after oral and I/V intake10%Gastric absorption is not affected by food14%
Exam Question Jul 2014
Exam Question Aug 2010
Diazepam is 95% protein bound and highly lipid soluble meaning that it readily crosses the blood brain barrier. The absorption rate is slowed by the presence of food. It has a long half life of 20-100 hours.
Benzodiazepines (pharmacokinetics)
Benzodiazepines are absorbed well following oral administration. They show high plasma protein binding (95% for diazepam). They are mainly metabolised in the liver. They tend to be highly lipophilic and rapidly cross the blood brain barrier and placental barrier.
