Which of the following is true regarding clozapine?
Clozapine (metabolism)
Clozapine is mainly metabolised by CYP1A2. Therefore inducers and inhibitors of CYP1A2 can have a profound effect on plasma clozapine levels.
Others mechanisms appear to be important including CYP2D6.
| Drug | Effect on plasma clozapine levels |
|---|---|
| SSRI's | Increased |
| Erythromycin | Increased |
| Caffeine | Increased |
| Carbamazepine | Decreased |
| Phenytoin | Decreased |
| Tobacco | Decreased |
The main 'active' metabolites (note: some sources regard the metabolites as inactive) are:
- N-desmethylclozapine (norclozapine)
- clozapine N-oxide
