Which of the following is most likely improve disturbed sleep-wake cycles in major depressive disorder?
Exam Question Apr 2012
Most antidepressants disrupt normal sleep architecture, particularly by supressing REM sleep. Agomelatine improves disturbed sleep-wake cycles in major depressive disorder.
Exam Question Apr 2012
Most antidepressants disrupt normal sleep architecture, particularly by supressing REM sleep. Agomelatine improves disturbed sleep-wake cycles in major depressive disorder.
Agomelatine
Agomelatine is a relatively new drug used for treating depression. It acts as an agonist at melatonin M1 and M2 receptors and as an antagonist at 5HT2C receptors.
The melatonin effects appear to promote sleep whereas the 5HT2C antagonism leads to the release of dopamine and norepinephrine in the frontal cortex. Interestingly serotonin levels appear not to be affected.
Maudsley Guidelines 10th Edition.
