Agomelatine acts as an agonist at which type of receptor?
Exam Question Aug 2010
Exam Question Aug 2010
Agomelatine
Agomelatine is a relatively new drug used for treating depression. It acts as an agonist at melatonin M1 and M2 receptors and as an antagonist at 5HT2C receptors.
The melatonin effects appear to promote sleep whereas the 5HT2C antagonism leads to the release of dopamine and norepinephrine in the frontal cortex. Interestingly serotonin levels appear not to be affected.
Maudsley Guidelines 10th Edition.
