Which of the following is not a recognised site of drug metabolism?
Drug metabolism
Metabolism refers to the process where a drug is changed from one form to another. One important function of metabolism is to convert lipid soluble drugs into a water soluble form so that they can then be excreted by the kidneys.
Drug metabolism is divided into two phases.
Phase 1 involves reduction or hydrolysis of the drug, but the most common biochemical process that occurs is oxidation.
Phase 2 involves conjugation, which is the attachment of an ionised group (which is very hydrophilic) to the drug.
The most common method is conjugation with glucuronic acid. Other added groups include sulphate, amino acids, acetate and methyl.
Drug metabolism takes place not only in the liver but also in the kidneys, intestine, and the lungs.
