Chromosomal location of disorders
Candidates for the MRCPsych need to be able to link genetic conditions to specific chromosomes.
| Chromosome | Conditions |
|---|---|
| 1 | Presenilin 2 (Alz), DISC-1 (Scz & BAD), DISC-2 (Scz), RGS-4 (Scz- interacts with neuregulin) |
| 2 | 2q- assoc with autistic spectrum disorder |
| 3 | Nothing |
| 4 | Huntingdon's Disease (CAG trinucleotide repeat-4p), Wolf-Hirschlorn 4p |
| 5 | Cri-du Chat (terminal deletion 5p) |
| 6 | Dysbindin(Scz-6p), PREP (mood disorder 6q) |
| 7 | 7q assoc with ASD (autistic spectrum disorder), Williams syndrome (microdeletion) |
| 8 | Neuregulin-1 (Scz & BAD- 8p) |
| 9 | Tuberose Sclerosis I |
| 10 | Nothing |
| 11 | Brain-Derived Neurotrophic Factor (BAD-rapid cycling 11p) |
| 12 | Assoc with trait neuroticism |
| 13 | Patau's syndrome (trisomy), Wilson's disease (ATP7B), DAO-A (Sch & BAD- 11q) |
| 14 | Presenilin 1 (Alz D) |
| 15 | Prader-Willi (paternal microdeletion), Angelman's (maternal microdeletion) |
| 16 | Assoc with ASD (autistic spectrum disorder)-16p, Tuberose Sclerosis II |
| 17 | Familial frontotemporal dementia, Smith-Magenis-17p, Neurofibromatosis 1 -17q |
| 18 | Edward's syndrome (trisomy) |
| 19 | ApoE (Alz & Vasc), Notch 3 (CADASIL), assoc with ASD (autistic spectrum disorder) |
| 20 | PrP (inherited CJD) |
| 21 | Amyloid Precursor Protein (Alz), Down's Syndrome (trisomy) |
| 22 | Neurofibromatosis 2, DiGeorge Syndrome (velocardiofacial), COMT (Scz & BAD) |
| X/Y | Fragile X, Lesch-Nyan (purines), Turners XO, Klinefelter's XXY |
