Glycine
Glycine binds to a receptor which makes the post-synaptic membrane more permeable to Cl- ion. This hyperpolarizes the membrane, making it less likely to depolarize. Thus, glycine is an inhibitory neurotransmitter.
Strychnine is a glycine antagonist which can bind to the glycine receptor without opening the chloride ion-channel (i.e., it inhibits inhibition). The resultant spinal hyperexcitability is what makes strychnine a poison.
Strychnine is a glycine antagonist which can bind to the glycine receptor without opening the chloride ion-channel (i.e., it inhibits inhibition). The resultant spinal hyperexcitability is what makes strychnine a poison.
