Progressive supranuclear palsy (pathology)
Progressive supranuclear palsy is rare disorder, which causes problems with gait and balance. It is often associated with alterations of mood and behaviour and also with dementia.
Macroscopic changes include:-
Microscopic changes include:-
Macroscopic changes include:-
- Pallor of substantia nigra (with sparing of the locus coeruleus)
- Mild midbrain atrophy
- Atrophy of the superior cerebellar peduncles
- Discolouration of the dentate nucleus
Microscopic changes include:-
- Gliosis
- Neurofibrillary tangles and tau inclusions in both astrocytes and oligodendrocytes (coiled bodies), particularly in the substantia nigra, subthalamic nucleus and globus pallidus.
